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Contents: April 2008, Volume 2008, Issue 1   [Index by Author]      Basic Science-Clinical Interface Sessions        Cancer Therapeutics        DNA Damage and Repair        Targeting Akt in Cancer: Promise, Progress, and Potential Pitfalls        Targeting the Insulin-like Growth Factor (IGF) System as a Cancer Therapy        Met Therapeutics in Clinical Trials        TGF-β Blockade as Anticancer Therapy        Epidermal Growth Factor Receptor as a Therapeutic Target        Folates        mTOR        Her2        Mitosis Inhibitors        Targeting the Proteasome Pathway        Targeting Tumor Angiogenesis: VEGF and Beyond     Educational Sessions        Cancer Research in the Elderly        Drug Resistance        Go/No-Go Decisions in Clinical Trials        Modifiable Risk Factors for Cancer        Serum Biomarkers        Cancer Susceptibility: Environment - Gene Interaction        From Chemistry to the Clinic: Pathways for Drug Discovery and Development-- Part 1: Early Discovery and Lead Generation        From Chemistry to the Clinic: Pathways for Drug Discovery and Development-- Part 2: Kinase Target Discovery and Inhibitor Development        Hypoxia        Natural Products in Anticancer Drug Discovery        Understanding Transcription        Cell Death and Autophagy        Chronic Infection and Carcinogenesis: Biology and Application        Clinical Implications of the Cancer Stem Cell Hypothesis        Imaging the Tumor Microenvironment        Smoking, Exercise, and Diet in Cancer Survivors: Translational Research Opportunities        Combination Therapy with Radiation        From Chemistry to the Clinic: Pathways for Drug Discovery and Development-- Part 4: Chemical Development: Translating a Potent Agent into a Registered Product        Mechanisms of Site-specific Metastasis        Pharmacogenomics        Targeting the Hedgehog Pathway in Cancer        The Role of Cellular Senescence in Tumorigenesis and Cancer Therapy        Understanding Intraepithelial Neoplasia     Methods Workshops        Imaging        Molecular Analysis from Formalin-fixed Paraffin-embedded Tissue Blocks        Translational Bioinformatics: Bytes to Bedside and Back        Molecular Cancer Epidemiology        New Technologies for the Development of Preclinical Mouse Models of Cancer        Structure-based Drug Design: An Indispensable Tool for Anticancer Drug Discovery        Circulating Tumor Cells        Clinical Trial Design Workshop Part 1: A Journey from Classical to Innovative Approaches        Epigenomics        Clinical Trial Design Workshop Part 2: A Journey from Classical to Innovative Approaches        Methods for the Study of MicroRNA Biology        Nanotechnology and Cancer        Pharmacokinetic Applications in Drug Development        From Chemistry to the Clinic: Pathways for Drug Discovery and Development-- Part 3: Optimizing Drug Discovery: Insights on an Important Process

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Basic Science-Clinical Interface Sessions:

Cancer Therapeutics:

Roch Houot and Ronald Levy

Therapeutic Vaccine for Lymphoma: Lessons Learned and Future Directions
Am Assoc Cancer Res Educ Book 2008: 3-11. doi: 10.1158/AACR.EDB-08-8185. [Full Text] [PDF]  

DNA Damage and Repair:

Leona D Samson

Introduction
Am Assoc Cancer Res Educ Book 2008: 14. doi: 10.1158/AACR.EDB-08-1007. [Full Text] [PDF] [Related Articles from AACR Journals]  

Elizabeth Ruth Plummer and Hilary Calvert

Targeting Poly(ADP-Ribose) Polymerase: A Two-Armed Strategy for Cancer Therapy
Am Assoc Cancer Res Educ Book 2008: 15-22.
Reprinted from Clin Cancer Res 2007 13: 6252-6256. doi: 10.1158/AACR.EDB-CCR-07-0617. [Abstract] [Full Text] [PDF]  

Targeting Akt in Cancer: Promise, Progress, and Potential Pitfalls:

Phillip A Dennis

Introduction
Am Assoc Cancer Res Educ Book 2008: 24. doi: 10.1158/AACR.EDB-08-962. [Full Text] [PDF]  

Phillip A Dennis

Targeting Akt in Cancer: Promise, Progress, and Potential Pitfalls
Am Assoc Cancer Res Educ Book 2008: 25-35. doi: 10.1158/AACR.EDB-08-8183. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Targeting the Insulin-like Growth Factor (IGF) System as a Cancer Therapy:

Douglas Yee

Introduction
Am Assoc Cancer Res Educ Book 2008: 38. doi: 10.1158/AACR.EDB-08-934. [Full Text] [PDF]  

Deepali Sachdev and Douglas Yee

Disrupting Insulin-Like Growth Factor Signaling as a Potential Cancer Therapy
Am Assoc Cancer Res Educ Book 2008: 39-58.
Reprinted from Mol Cancer Ther 2007 6: 1-12. doi: 10.1158/AACR.EDB-MCT-06-0080. [Abstract] [Full Text] [PDF]  

Met Therapeutics in Clinical Trials:

George F Vande Woude

Introduction
Am Assoc Cancer Res Educ Book 2008: 60. doi: 10.1158/AACR.EDB-08-943. [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Benedetta Peruzzi and Donald P Bottaro

Targeting the c-Met Signaling Pathway in Cancer
Am Assoc Cancer Res Educ Book 2008: 61-68.
Reprinted from Clin Cancer Res 2006 12: 3657-3660. doi: 10.1158/AACR.EDB-CCR-06-0818. [Abstract] [Full Text] [PDF]  

TGF-β Blockade as Anticancer Therapy:

Beverly A Teicher

Introduction
Am Assoc Cancer Res Educ Book 2008: 70. doi: 10.1158/AACR.EDB-08-918. [Full Text] [PDF]  

Beverly A Teicher, Jonathan M Yingling, and John M McPherson

TGFβ Blockade as Anticancer Therapy
Am Assoc Cancer Res Educ Book 2008: 71-81. doi: 10.1158/AACR.EDB-08-8179. [Abstract] [Full Text] [PDF]  

Epidermal Growth Factor Receptor as a Therapeutic Target:

Adi F Gazdar

EGFR Signaling Pathway Deregulation in Lung Cancer and Its Clinical Significance
Am Assoc Cancer Res Educ Book 2008: 85-89. doi: 10.1158/AACR.EDB-08-8039. [Abstract] [Full Text] [PDF] [Related Articles from AACR Journals]  

Maurizio Scaltriti and José Baselga

The Epidermal Growth Factor Receptor Pathway: A Model for Targeted Therapy
Am Assoc Cancer Res Educ Book 2008: 91-98.
Reprinted from Clin Cancer Res 2006 12: 5268-5272. doi: 10.1158/AACR.EDB-CCR-06-1554. [Abstract] [Full Text] [PDF]  

Folates:

Ann L Jackman

Exploiting Folate Pathways and Transporters for the Management and Treatment of Cancer
Am Assoc Cancer Res Educ Book 2008: 101-108. doi: 10.1158/AACR.EDB-08-8184. [Abstract] [Full Text] [PDF]  

mTOR:

Peter J Houghton, John B Easton, and Raushan T Kurmasheva

mTOR as a Target for Cancer Therapy
Am Assoc Cancer Res Educ Book 2008: 111-120. doi: 10.1158/AACR.EDB-08-8182. [Abstract] [Full Text] [PDF] [Related Articles from AACR Journals]  

Her2:

Nancy E Hynes

Introduction
Am Assoc Cancer Res Educ Book 2008: 122. doi: 10.1158/AACR.EDB-08-883. [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Nancy E Hynes

ErbB Receptors in Cancer: HER2/ErbB2 as a Therapeutic Target
Am Assoc Cancer Res Educ Book 2008: 123-130. doi: 10.1158/AACR.EDB-08-8177. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Mitosis Inhibitors:

Travis L Schmit and Nihal Ahmad

Regulation of Mitosis via Mitotic Kinases: New Opportunities for Cancer Management
Am Assoc Cancer Res Educ Book 2008: 133-150.
Reprinted from Mol Cancer Ther 2007 6: 1920-1931. doi: 10.1158/AACR.EDB-MCT-06-0781. [Abstract] [Full Text] [PDF] [Related Articles from AACR Journals]  

Targeting the Proteasome Pathway:

Julian Adams

Introduction
Am Assoc Cancer Res Educ Book 2008: 152. doi: 10.1158/AACR.EDB-08-894. [Full Text] [PDF] [Related Articles from AACR Journals]  

Peter M Voorhees, E Claire Dees, Bert O'Neil, and Robert Z Orlowski

The Proteasome as a Target for Cancer Therapy
Am Assoc Cancer Res Educ Book 2008: 153-170.
Reprinted from Clin Cancer Res 2003 9: 6316-6325. [Abstract] [Full Text] [PDF]  

Targeting Tumor Angiogenesis: VEGF and Beyond:

Gregory D Plowman

Introduction
Am Assoc Cancer Res Educ Book 2008: 172. doi: 10.1158/AACR.EDB-08-875. [Full Text] [PDF] [Related Articles from AACR Journals]  

Marcin Kowanetz and Napoleone Ferrara

Vascular Endothelial Growth Factor Signaling Pathways: Therapeutic Perspective
Am Assoc Cancer Res Educ Book 2008: 173-181.
Reprinted from Clin Cancer Res 2006 12: 5018-5022. doi: 10.1158/AACR.EDB-CCR-06-1520. [Abstract] [Full Text] [PDF]  

Educational Sessions:

Cancer Research in the Elderly:

Ludovico Balducci

Introduction
Am Assoc Cancer Res Educ Book 2008: 184. doi: 10.1158/AACR.EDB-08-553. [Full Text] [PDF]  

Irmgard Irminger-Finger

Cellular and Molecular Crossroads of Cancer and Aging
Am Assoc Cancer Res Educ Book 2008: 185-189. doi: 10.1158/AACR.EDB-08-8108. [Abstract] [Full Text] [PDF]  

William B Ershler

Influence of the Oldest Tumor Host on Tumor Biology
Am Assoc Cancer Res Educ Book 2008: 191-195. doi: 10.1158/AACR.EDB-08-8109. [Abstract] [Full Text] [PDF]  

Lodovico Balducci

Clinical Research in Older Cancer Patients
Am Assoc Cancer Res Educ Book 2008: 197-200. doi: 10.1158/AACR.EDB-08-8111. [Full Text] [PDF]  

Drug Resistance:

Herbert M Pinedo

Introduction
Am Assoc Cancer Res Educ Book 2008: 202. doi: 10.1158/AACR.EDB-08-445. [Full Text] [PDF]  

Lee M Ellis

Resistance to Anti-VEGF Therapy
Am Assoc Cancer Res Educ Book 2008: 203-207. doi: 10.1158/AACR.EDB-08-8074. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Lloyd R Kelland

DNA Repair Enzymes and Platinum Drug Resistance in Tumors
Am Assoc Cancer Res Educ Book 2008: 209-213. doi: 10.1158/AACR.EDB-08-8077. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Go/No-Go Decisions in Clinical Trials:

Eric H Rubin

Introduction
Am Assoc Cancer Res Educ Book 2008: 216. doi: 10.1158/AACR.EDB-08-621. [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides][Related Articles from AACR Journals]  

Weichung Joe Shih

Go/No-Go Decisions from Phase II to Phase III Clinical Trials
Am Assoc Cancer Res Educ Book 2008: 217-221. doi: 10.1158/AACR.EDB-08-8131. [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Modifiable Risk Factors for Cancer:

Leslie Bernstein

Introduction
Am Assoc Cancer Res Educ Book 2008: 224. doi: 10.1158/AACR.EDB-08-517. [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Leslie Bernstein

Physical Activity and Cancer
Am Assoc Cancer Res Educ Book 2008: 225-231. doi: 10.1158/AACR.EDB-08-8102. [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Graham A Colditz

Oral Contraceptives, Postmenopausal Hormones, and Breast Cancer
Am Assoc Cancer Res Educ Book 2008: 233-236. doi: 10.1158/AACR.EDB-08-8103. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Serum Biomarkers:

Samir N Khleif

Introduction
Am Assoc Cancer Res Educ Book 2008: 238. doi: 10.1158/AACR.EDB-08-423. [Full Text] [PDF] [Related Articles from AACR Journals]  

Padma Maruvada and Sudhir Srivastava

Joint National Cancer Institute-Food and Drug Administration Workshop on Research Strategies, Study Designs, and Statistical Approaches to Biomarker Validation for Cancer Diagnosis and Detection
Am Assoc Cancer Res Educ Book 2008: 239-247.
Reprinted from Cancer Epidemiol Biomarkers Prev 2006 15: 1078-1082. doi: 10.1158/AACR.EDB-EPI-05-0432. [Abstract] [Full Text] [PDF]  

Cancer Susceptibility: Environment - Gene Interaction:

Suzanne D Conzen

Introduction
Am Assoc Cancer Res Educ Book 2008: 250. doi: 10.1158/AACR.EDB-08-659. [Full Text] [PDF]  

Adi F Gazdar

Lung Cancer in Never Smokers
Am Assoc Cancer Res Educ Book 2008: 251-254. doi: 10.1158/AACR.EDB-08-8080. [Abstract] [Full Text] [PDF]  

Suzanne D Conzen

Environmental Stress and the Neuroendocrine Response: Is There a Cancer Connection?
Am Assoc Cancer Res Educ Book 2008: 255-262. doi: 10.1158/AACR.EDB-08-8081. [Abstract] [Full Text] [PDF]  

From Chemistry to the Clinic: Pathways for Drug Discovery and Development-- Part 1: Early Discovery and Lead Generation:

Arie Zask

Introduction
Am Assoc Cancer Res Educ Book 2008: 264. doi: 10.1158/AACR.EDB-08-5643. [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Ariamala Gopalsamy

Hit to Lead Generation for Oncology Targets
Am Assoc Cancer Res Educ Book 2008: 265-267. doi: 10.1158/AACR.EDB-08-8250. [Full Text] [PDF]  

Maurizio Pellecchia, Jun Wei, Shinichi Kitada, Michele F Rega, and John C Reed

Targeting Apoptosis via Chemical Design
Am Assoc Cancer Res Educ Book 2008: 269-273. doi: 10.1158/AACR.EDB-08-8254. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Natasja Brooijmans

Computational Chemistry in Early-Stage Drug Discovery
Am Assoc Cancer Res Educ Book 2008: 275-277. doi: 10.1158/AACR.EDB-08-8252. [Full Text] [PDF]  

From Chemistry to the Clinic: Pathways for Drug Discovery and Development-- Part 2: Kinase Target Discovery and Inhibitor Development:

Matt V Lorenzi

Introduction
Am Assoc Cancer Res Educ Book 2008: 280. doi: 10.1158/AACR.EDB-08-5628. [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

William C Hahn

Integrative Approaches to Identify and Validate Kinase Oncogenes
Am Assoc Cancer Res Educ Book 2008: 281-284. doi: 10.1158/AACR.EDB-08-8235. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Hypoxia:

Richard P Hill

Introduction
Am Assoc Cancer Res Educ Book 2008: 286. doi: 10.1158/AACR.EDB-08-8056. [Full Text] [PDF]  

Robert G Bristow

Hypoxia, DNA Repair, and Genetic Instability
Am Assoc Cancer Res Educ Book 2008: 287-291. doi: 10.1158/AACR.EDB-08-8388. [Abstract] [Full Text] [PDF]  

William R Wilson, Kevin O Hicks, Frederik B Pruijn, and Adam V Patterson

Targeting Tumor Hypoxia with Prodrugs: Challenges and Opportunities
Am Assoc Cancer Res Educ Book 2008: 293-310. doi: 10.1158/AACR.EDB-08-8390. [Abstract] [Full Text] [PDF]  

Natural Products in Anticancer Drug Discovery:

Sidney M Hecht

Introduction
Am Assoc Cancer Res Educ Book 2008: 304. doi: 10.1158/AACR.EDB-08-8415. [Full Text] [PDF]  

David G I Kingston

Tubulin-Interactive Natural Products as Anticancer Agents
Am Assoc Cancer Res Educ Book 2008: 305-313. doi: 10.1158/AACR.EDB-08-8125. [Abstract] [Full Text] [PDF]  

Daekyu Sun and Laurence H Hurley

Telomestatin as a Structural Probe for Targeting G-quadruplexes in Telomeric and Promoter Regions
Am Assoc Cancer Res Educ Book 2008: 315-318. doi: 10.1158/AACR.EDB-08-8126. [Abstract] [Full Text] [PDF]  

Sidney M Hecht

Natural Products that Bind to Heat Shock Protein 90
Am Assoc Cancer Res Educ Book 2008: 319-325. doi: 10.1158/AACR.EDB-08-8416. [Abstract] [Full Text] [PDF]  

Understanding Transcription:

Lorraine J Gudas

Introduction
Am Assoc Cancer Res Educ Book 2008: 328. doi: 10.1158/AACR.EDB-08-473. [Full Text] [PDF]  

Jonathan D Licht

Understanding Transcription and Epigenetic Modifications
Am Assoc Cancer Res Educ Book 2008: 329-334. doi: 10.1158/AACR.EDB-08-8085. [Abstract] [Full Text] [PDF]  

David A Frank

Targeting Transcription Factors for Cancer Therapy
Am Assoc Cancer Res Educ Book 2008: 335-341. doi: 10.1158/AACR.EDB-08-8083. [Abstract] [Full Text] [PDF]  

Cell Death and Autophagy:

Wafik S El-Deiry

Introduction
Am Assoc Cancer Res Educ Book 2008: 344. doi: 10.1158/AACR.EDB-08-504. [Full Text] [PDF]  

Eileen White

Autophagy and Apoptosis Modulation in Cancer Therapy
Am Assoc Cancer Res Educ Book 2008: 345-348. doi: 10.1158/AACR.EDB-08-8092. [Abstract] [Full Text] [PDF]  

Loren D Walensky

Multimodal Targeting of the BCL-2 Family in Cancer
Am Assoc Cancer Res Educ Book 2008: 349-356. doi: 10.1158/AACR.EDB-08-8093. [Abstract] [Full Text] [PDF]  

Chronic Infection and Carcinogenesis: Biology and Application:

Charles S Rabkin

Introduction
Am Assoc Cancer Res Educ Book 2008: 358. doi: 10.1158/AACR.EDB-08-571. [Full Text] [PDF]  

Charles S Rabkin

Molecular Epidemiology of Infection-Related Malignancy
Am Assoc Cancer Res Educ Book 2008: 359-361. doi: 10.1158/AACR.EDB-08-8113. [Abstract] [Full Text] [PDF]  

Lawrence S Young

Epstein-Barr Virus Infection: From Persistence to Pathogenesis
Am Assoc Cancer Res Educ Book 2008: 363-366. doi: 10.1158/AACR.EDB-08-8114. [Abstract] [Full Text] [PDF]  

Eduardo L Franco

Human Papillomavirus and Cervical Cancer: Integrating the New Prevention Strategies
Am Assoc Cancer Res Educ Book 2008: 367-373. doi: 10.1158/AACR.EDB-08-8115. [Abstract] [Full Text] [PDF]  

James G Fox

Helicobacter-Associated Chronic Inflammation and Gastrointestinal Cancer
Am Assoc Cancer Res Educ Book 2008: 375-380. doi: 10.1158/AACR.EDB-08-8116. [Full Text] [PDF]  

Clinical Implications of the Cancer Stem Cell Hypothesis:

Max S Wicha

Introduction
Am Assoc Cancer Res Educ Book 2008: 382. doi: 10.1158/AACR.EDB-08-468. [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides][Related Articles from AACR Journals]  

Max S Wicha, Suling Liu, and Gabriela Dontu

Cancer Stem Cells: An Old Idea—A Paradigm Shift
Am Assoc Cancer Res Educ Book 2008: 383-396.
Reprinted from Cancer Res 2006 66: 1883-1890. doi: 10.1158/AACR.EDB-CAN-05-3153. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Saranya Chumsri, William Matsui, and Angelika M Burger

Therapeutic Implications of Leukemic Stem Cell Pathways
Am Assoc Cancer Res Educ Book 2008: 397-406.
Reprinted from Clin Cancer Res 2007 13: 6549-6554. doi: 10.1158/AACR.EDB-CCR-07-1088. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Imaging the Tumor Microenvironment:

Lynn M Matrisian

Introduction
Am Assoc Cancer Res Educ Book 2008: 408. doi: 10.1158/AACR.EDB-08-541. [Full Text] [PDF] [Related Articles from AACR Journals]  

Bonnie F Sloane, Robert J Gillies, Suresh Mohla, John A Sogn, Anne E Menkens, and Daniel C Sullivan

I2 Imaging: Cancer Biology and the Tumor Microenvironment
Am Assoc Cancer Res Educ Book 2008: 409-413.
Reprinted from Cancer Res 2006 66: 11097-11099. doi: 10.1158/AACR.EDB-CAN-06-3102. [Abstract] [Full Text] [PDF]  

Smoking, Exercise, and Diet in Cancer Survivors: Translational Research Opportunities:

Jimmie C Holland

Introduction
Am Assoc Cancer Res Educ Book 2008: 416. doi: 10.1158/AACR.EDB-08-601. [Full Text] [PDF]  

Kerry S Courneya

Physical Activity in Cancer Survivors: Possible Associations with Clinical Outcomes
Am Assoc Cancer Res Educ Book 2008: 417-420. doi: 10.1158/AACR.EDB-08-8123. [Abstract] [Full Text] [PDF]  

Combination Therapy with Radiation:

Bruce G Haffty

Introduction
Am Assoc Cancer Res Educ Book 2008: 422. doi: 10.1158/AACR.EDB-08-589. [Full Text] [PDF]  

James A Bonner and Jimmy J Caudell

Combining Radiation with Biological Agents: Focus on the Inhibition of Epidermal Growth Factor Receptor
Am Assoc Cancer Res Educ Book 2008: 423-426. doi: 10.1158/AACR.EDB-08-8120. [Abstract] [Full Text] [PDF]  

From Chemistry to the Clinic: Pathways for Drug Discovery and Development-- Part 4: Chemical Development: Translating a Potent Agent into a Registered Product:

Stephen A Munk

Introduction
Am Assoc Cancer Res Educ Book 2008: 428. doi: 10.1158/AACR.EDB-08-1665. [Full Text] [PDF]  

William E Bauta, Brian E Schulmeier, William R Cantrell, Jr, Bruce Anderson, Brian Burke, Dennis Lovett, James Goebel, Philip Bauer, Dumitru Ionescu, and Ruichao Guo

Chemical Manufacturing and Controls: Adventures in Development of a Nucleoside Antimetabolite
Am Assoc Cancer Res Educ Book 2008: 429-432. doi: 10.1158/AACR.EDB-08-8241. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Lidia C Sambucetti, Masato Tanabe, Wan-Ru Chao, Nurulain Zaveri, Peter Hobbs, Ling Jong, Richard H Peters, Barbara Sato, Cris Olsen, Mary Tanga, Helen Jaber Parish, Nathan Collins, and Jon Mirsalis

Chemical Development of Novel Cancer Therapeutic Agents: Case Studies in the Development of Tissue-Selective, Estrogen Receptor Modulators (SERMs).
Am Assoc Cancer Res Educ Book 2008: 433-436. doi: 10.1158/AACR.EDB-08-8244. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

James R Porter, Rebecca Ahn, Vince Ammoscato, Brian C Austad, Johan Basuki, Marlene R Booth, Matthew J Campbell, Bennett Carter, Michael Curtis, Mark A Douglas, Louis Grenier, Elizabeth A Grieco, Joseph Helble, Edward B Holson, Natalie Hosking, Jennifer Hoyt, Dumitru Ionescu, Laila Kott, Jason T Kropp, John Lee, Kaiming Li, Bradley Maurer, Roger H Pak, Jason Piotrowski, Jennifer R Porter, David Rusch, Geoff E Sylvester, Steven Wong, and Jim Wright

Pharmaceutical Development of IPI-504, an Aqueous Soluble Analog of 17-AAG and Potent Inhibitor of Hsp90
Am Assoc Cancer Res Educ Book 2008: 437-439. doi: 10.1158/AACR.EDB-08-8246. [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Mechanisms of Site-specific Metastasis:

Lauren A Kingsley, Pierrick G J Fournier, John M Chirgwin, and Theresa A Guise

Molecular Biology of Bone Metastasis
Am Assoc Cancer Res Educ Book 2008: 443-457.
Reprinted from Mol Cancer Ther 2007 6: 2609-2617. doi: 10.1158/AACR.EDB-MCT-07-0234. [Abstract] [Full Text] [PDF] [Related Articles from AACR Journals]  

Pharmacogenomics:

Robert B Diasio

Introduction
Am Assoc Cancer Res Educ Book 2008: 460. doi: 10.1158/AACR.EDB-08-435. [Full Text] [PDF]  

Robert B Diasio

Overview of Cancer Pharmacogenomics
Am Assoc Cancer Res Educ Book 2008: 461-464. doi: 10.1158/AACR.EDB-08-8069. [Abstract] [Full Text] [PDF]  

Daniel J Schaid

Overview of Statistical Genetic Concepts for Pharmacogenomic Studies
Am Assoc Cancer Res Educ Book 2008: 465-469. doi: 10.1158/AACR.EDB-08-8071. [Abstract] [Full Text] [PDF]  

Hany H Ezzeldin

Challenges in Pharmacogenomic Testing
Am Assoc Cancer Res Educ Book 2008: 471-476. doi: 10.1158/AACR.EDB-08-8072. [Abstract] [Full Text] [PDF]  

Targeting the Hedgehog Pathway in Cancer:

Frederic J De Sauvage

Introduction
Am Assoc Cancer Res Educ Book 2008: 478. doi: 10.1158/AACR.EDB-08-628. [Full Text] [PDF]  

Marie Evangelista, Hua Tian, and Frederic J de Sauvage

The Hedgehog Signaling Pathway in Cancer
Am Assoc Cancer Res Educ Book 2008: 479-486.
Reprinted from Clin Cancer Res 2006 12: 5924-5928. doi: 10.1158/AACR.EDB-CCR-06-1736. [Abstract] [Full Text] [PDF]  

Roel Nusse

Wnt Signaling, Stem Cells, and Cancer
Am Assoc Cancer Res Educ Book 2008: 487-490. doi: 10.1158/AACR.EDB-08-8133. [Full Text] [PDF]  

Paola Rizzo, Clodia Osipo, Kimberly Foreman, Jieun Yun, Todd Golde, Barbara Osborne, and Lucio Miele

Rational Targeting of Notch in Breast Cancer
Am Assoc Cancer Res Educ Book 2008: 491-495. doi: 10.1158/AACR.EDB-08-8135. [Abstract] [Full Text] [PDF]  

The Role of Cellular Senescence in Tumorigenesis and Cancer Therapy:

Laura D Attardi

Introduction
Am Assoc Cancer Res Educ Book 2008: 498. doi: 10.1158/AACR.EDB-08-641. [Full Text] [PDF]  

Clemens A Schmitt

In vivo Complexities of Cellular Senescence in Tumor Development and Therapy
Am Assoc Cancer Res Educ Book 2008: 499-504. doi: 10.1158/AACR.EDB-08-8138. [Abstract] [Full Text] [PDF]  

Judith Campisi

Protumorigenic Effects of the Senescence-Associated Secretory Phenotype
Am Assoc Cancer Res Educ Book 2008: 505-509. doi: 10.1158/AACR.EDB-08-8139. [Abstract] [Full Text] [PDF]  

Understanding Intraepithelial Neoplasia:

Eva Szabo

Introduction
Am Assoc Cancer Res Educ Book 2008: 512. doi: 10.1158/AACR.EDB-08-482. [Full Text] [PDF]  

Adam B Glick

The High Risk Premalignant Lesion: Experimental Evidence and Clinical Implications
Am Assoc Cancer Res Educ Book 2008: 513-516. doi: 10.1158/AACR.EDB-08-8087. [Abstract] [Full Text] [PDF]  

Methods Workshops:

Imaging:

Martin G Pomper

Introduction
Am Assoc Cancer Res Educ Book 2008: 518. doi: 10.1158/AACR.EDB-08-705. [Full Text] [PDF] [Related Articles from AACR Journals]  

Zaver M Bhujwalla

Molecular Imaging of the Tumor Microenvironment
Am Assoc Cancer Res Educ Book 2008: 519-522. doi: 10.1158/AACR.EDB-08-8144. [Abstract] [Full Text] [PDF]  

John Kurhanewicz

Magnetic Resonance Imaging Biomarkers of Prostate Cancer
Am Assoc Cancer Res Educ Book 2008: 523-526. doi: 10.1158/AACR.EDB-08-8146. [Abstract] [Full Text] [PDF]  

Molecular Analysis from Formalin-fixed Paraffin-embedded Tissue Blocks:

Dennis C Sgroi

Introduction
Am Assoc Cancer Res Educ Book 2008: 528. doi: 10.1158/AACR.EDB-08-819. [Full Text] [PDF]  

Dennis Sgroi

Real-Time PCR Biomarker Analysis Using Routine Pathology Specimens
Am Assoc Cancer Res Educ Book 2008: 529-530. doi: 10.1158/AACR.EDB-08-8226. [Full Text] [PDF]  

Sunil Badve

Reviving the Dead: DASL Expression Analysis from Paraffin
Am Assoc Cancer Res Educ Book 2008: 531-533. doi: 10.1158/AACR.EDB-08-8228. [Abstract] [Full Text] [PDF]  

Translational Bioinformatics: Bytes to Bedside and Back:

Gunaretnam Rajagopal

Introduction
Am Assoc Cancer Res Educ Book 2008: 536. doi: 10.1158/AACR.EDB-08-741. [Full Text] [PDF]  

Kenneth H Buetow

The Cancer Biomedical Informatics Grid (caBIG^TM): Creating a Platform for Personalized, Molecular Medicine
Am Assoc Cancer Res Educ Book 2008: 537-539. doi: 10.1158/AACR.EDB-08-8150. [Abstract] [Full Text] [PDF]  

Frank Eisenhaber

Pharmaceutical Target Identification within the Sequence-Analytic Framework of the ANNOTATOR Environment
Am Assoc Cancer Res Educ Book 2008: 541-544. doi: 10.1158/AACR.EDB-08-8151. [Abstract] [Full Text] [PDF]  

Molecular Cancer Epidemiology:

Paolo Boffetta

Introduction
Am Assoc Cancer Res Educ Book 2008: 546. doi: 10.1158/AACR.EDB-08-807. [Full Text] [PDF]  

Paolo Vineis and Frederica Perera

Molecular Epidemiology and Biomarkers in Etiologic Cancer Research: The New in Light of the Old
Am Assoc Cancer Res Educ Book 2008: 547-567.
Reprinted from Cancer Epidemiol Biomarkers Prev 2007 16: 1954-1965. doi: 10.1158/AACR.EDB-EPI-07-0457. [Abstract] [Full Text] [PDF]  

New Technologies for the Development of Preclinical Mouse Models of Cancer:

Corey Abate-Shen

Introduction
Am Assoc Cancer Res Educ Book 2008: 570. doi: 10.1158/AACR.EDB-08-773. [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides][Related Articles from AACR Journals]  

Beverly A Teicher

Tumor Models for Efficacy Determination
Am Assoc Cancer Res Educ Book 2008: 571-585.
Reprinted from Mol Cancer Ther 2006 5: 2435-2443. doi: 10.1158/AACR.EDB-MCT-06-0391. [Abstract] [Full Text] [PDF]  

Structure-based Drug Design: An Indispensable Tool for Anticancer Drug Discovery:

William J Welsh

Introduction
Am Assoc Cancer Res Educ Book 2008: 588. doi: 10.1158/AACR.EDB-08-845. [Full Text] [PDF] [Related Articles from AACR Journals]  

Ariel Fernández, Angela Sanguino, Zhenghong Peng, Alejandro Crespo, Eylem Ozturk, Xi Zhang, Shimei Wang, William Bornmann, and Gabriel Lopez-Berestein

Rational Drug Redesign to Overcome Drug Resistance in Cancer Therapy: Imatinib Moving Target
Am Assoc Cancer Res Educ Book 2008: 589-599.
Reprinted from Cancer Res 2007 67: 4028-4033. doi: 10.1158/AACR.EDB-CAN-07-0345. [Abstract] [Full Text] [PDF]  

Circulating Tumor Cells:

Klaus Pantel, Catherine Alix-Panabières, and Sabine Riethdorf

Circulating Tumor Cells: Detection and Clinical Relevance
Am Assoc Cancer Res Educ Book 2008: 603-610. doi: 10.1158/AACR.EDB-08-8156. [Abstract] [Full Text] [PDF]  

Catherine Alix-Panabières and Klaus Pantel

EPISPOT Assay: Detection of Proteins Secreted by Viable Disseminating Tumor Cells in Solid Tumor Patients
Am Assoc Cancer Res Educ Book 2008: 611-615. doi: 10.1158/AACR.EDB-08-8158. [Abstract] [Full Text] [PDF]  

M Craig Miller, Gerald V Doyle, and Leon W M M Terstappen

Monitoring and Characterization of CTC in Cancer Patients
Am Assoc Cancer Res Educ Book 2008: 617-624. doi: 10.1158/AACR.EDB-08-8157. [Abstract] [Full Text] [PDF]  

Burkhard H Brandt

Single/Oligo-Cell PCR: Needs, Perspectives, and Limitations
Am Assoc Cancer Res Educ Book 2008: 625-628. doi: 10.1158/AACR.EDB-08-8257. [Abstract] [Full Text] [PDF]  

Clinical Trial Design Workshop Part 1: A Journey from Classical to Innovative Approaches:

J Jack Lee, UT and Lillian L Siu

Introduction
Am Assoc Cancer Res Educ Book 2008: 630. doi: 10.1158/AACR.EDB-08-803. [Full Text] [PDF]  

J Jack Lee

Adaptive Designs for Efficacy and Toxicity Endpoints in Early Drug Development
Am Assoc Cancer Res Educ Book 2008: 631-636. doi: 10.1158/AACR.EDB-08-8160. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Yu Shyr

Development and Validation of Biomarkers Derived from High Throughput Assays in Translational Research
Am Assoc Cancer Res Educ Book 2008: 637-639. doi: 10.1158/AACR.EDB-08-8162. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Epigenomics:

Jean-Pierre J Issa

DNA Methylation as a Therapeutic Target in Cancer
Am Assoc Cancer Res Educ Book 2008: 643-649.
Reprinted from Clin Cancer Res 2007 13: 1634-1637. doi: 10.1158/AACR.EDB-CCR-06-2076. [Abstract] [Full Text] [PDF] [Related Articles from AACR Journals]  

Chia Lin Wei and Yijun Ruan

Multiplex Sequencing of Pair-End-Ditags (MS-PET) for Cancer Genome Interrogation
Am Assoc Cancer Res Educ Book 2008: 651-656. doi: 10.1158/AACR.EDB-08-8437. [Abstract] [Full Text] [PDF]  

Clinical Trial Design Workshop Part 2: A Journey from Classical to Innovative Approaches:

J Jack Lee, UT and Lillian L Siu

Introduction
Am Assoc Cancer Res Educ Book 2008: 658. doi: 10.1158/AACR.EDB-08-805. [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Marc E Buyse

Surrogate Endpoints for Efficacy in Clinical Research: Working Definitions and Validation
Am Assoc Cancer Res Educ Book 2008: 659-663. doi: 10.1158/AACR.EDB-08-8214. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

Methods for the Study of MicroRNA Biology:

Scott M Hammond

Introduction
Am Assoc Cancer Res Educ Book 2008: 666. doi: 10.1158/AACR.EDB-08-700. [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

George Adrian Calin and Carlo Maria Croce

MicroRNA-Cancer Connection: The Beginning of a New Tale
Am Assoc Cancer Res Educ Book 2008: 667-675.
Reprinted from Cancer Res 2006 66: 7390-7394. doi: 10.1158/AACR.EDB-CAN-06-0800. [Abstract] [Full Text] [PDF]  

Nanotechnology and Cancer:

Mauro Ferrari

Introduction
Am Assoc Cancer Res Educ Book 2008: 678. doi: 10.1158/AACR.EDB-08-698. [Full Text] [PDF]  

Ennio Tasciotti, Fredika M Robertson, and Mauro Ferrari

Nanoporous Silicon as a Platform for Targeted Drug Delivery and Discovery of Proteomic Signatures for Cancer Diagnostics
Am Assoc Cancer Res Educ Book 2008: 679-685. doi: 10.1158/AACR.EDB-08-8140. [Abstract] [Full Text] [PDF]  

Mary E Napier, Stephanie E A Gratton, and Joseph M DeSimone

Monodisperse, Shape-Specific Nanobiomaterials for Cancer Therapeutics and Imaging Agents
Am Assoc Cancer Res Educ Book 2008: 687-692. doi: 10.1158/AACR.EDB-08-8141. [Abstract] [Full Text] [PDF]  

Pharmacokinetic Applications in Drug Development:

Sharyn D Baker and Alex Sparreboom

Introduction
Am Assoc Cancer Res Educ Book 2008: 694. doi: 10.1158/AACR.EDB-08-817. [Full Text] [PDF]  

Walter J Loos

Pharmacokinetic Concepts and Analytical Methodologies
Am Assoc Cancer Res Educ Book 2008: 695-699. doi: 10.1158/AACR.EDB-08-8167. [Abstract] [Full Text] [PDF]  

Alex Sparreboom

Pharmacokinetic Studies in Microdosing and Phase 0 Trials
Am Assoc Cancer Res Educ Book 2008: 701-703. doi: 10.1158/AACR.EDB-08-8169. [Abstract] [Full Text] [PDF]  

Sharyn D Baker

Pharmacokinetic Considerations for Molecularly Targeted Therapy
Am Assoc Cancer Res Educ Book 2008: 705-709. doi: 10.1158/AACR.EDB-08-8170. [Abstract] [Full Text] [PDF]  

Educational Sessions:

From Chemistry to the Clinic: Pathways for Drug Discovery and Development-- Part 3: Optimizing Drug Discovery: Insights on an Important Process:

Deborah Choquette, Longbin Liu, Tae-Seong Kim, Mark Norman, Aaron Siegmund, Ning Xi, Steven F Bellon, April Chen, Paula Kaplan-Lefko, Matthew Lee, Jasmine Lin, Karen Rex, Yohannes Teffera, Isabelle Dussault, and Jean-Christophe Harmange

Discovery of AMG 458: A Potent, Selective, and Orally Bioavailable c-Met Inhibitor
Am Assoc Cancer Res Educ Book 2008: 713-718. doi: 10.1158/AACR.EDB-08-8717. [Abstract] [Full Text] [PDF] [AACR Annual Meeting Webcast: Audio and Slides]  

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